Background: Tumour necrosis factor like cytokine 1A (TL1A), which is a member of tumour necrosis factor alpha superfamily (TNF-α), is a novel indicator of atherosclerosis.

Objective: Smoking is an established stimulant of TNF-α. We aimed to investigate whether TLA1 plays a role in the presence and complexity of coronary artery atherosclerosis, exclusively in non-smoking patients with CAD.

Methods: We enrolled 103 participants in the study, who underwent coronary angiography for stable angina pectoris. We divided the study population into 2 groups: The CAD group consisted of 62 patients with CAD and the control group consisted of 41 subjects with non-CAD. SYNTAX and Gensini scores, indicating CAD severity and complexity, were analysed as well as TLA1 levels.

Results: TLA1 levels was higher in patients with CAD than those in controls (228[119–824] vs 178[15–418]pg/ml, p < 0.001). Presence of CAD (β ± SE = 106.29 ± 33.11, p = 0.002), Syntax score (β ± SE= 6.57 ± 1.75, p = 0.012), and Gensini score (β ± SE = 2.30 ± 0.65, p = 0.001) were found to be predictors of TL1A levels. Gensini score and Syntax score were positively correlated with TL1A levels (r = 0.420, p < 0.001, and r = 0.402, p < 0.001, respectively).

Conclusions: Non-smoker CAD patients have higher TLA1 levels that are promising biomarker for diagnosing CAD and indicating CAD lesion complexity.

背景：肿瘤坏死因子，如细胞因子1A（TL1A），是肿瘤坏死因子α超家族（TNF-α）的成员，是动脉粥样硬化的一种新指标。

目的：吸烟是一种公认​​的TNF-α兴奋剂。我们旨在调查TLA1是否仅在非吸烟CAD患者中在冠状动脉粥样硬化的存在和复杂性中发挥作用。

方法：我们招募了103名参加研究的参与者，他们因稳定的心绞痛而接受了冠状动脉造影。我们将研究人群分为两组：CAD组由62例CAD患者组成，对照组由41例非CAD受试者组成。对SYNTAX和Gensini得分（表明CAD的严重程度和复杂性）以及TLA1水平进行了分析。

结果： CAD患者的TLA1水平高于对照组（228 [119-824] vs 178 [15-418] pg / ml，p  <0.001）。存在CAD（β ±SE = 106.29±33.11，p  = 0.002），语法评分（β ±SE = 6.57±1.75，p  = 0.012）和Gensini评分（β ±SE = 2.30±0.65，p  = 0.001）被发现是TL1A水平的预测因子。Gensini评分和Syntax评分与TL1A水平呈正相关（r  = 0.420，p  <0.001，r  = 0.402，p  <0.001）。

结论：不吸烟的CAD患者的TLA1水平较高，有望成为诊断CAD和表明CAD病变复杂性的生物标志物。