Lipid nitration occurs during physiological and pathophysiological conditions, generating a variety of biomolecules capable to modulate inflammatory cell responses. Low-density lipoprotein (LDL) oxidation has been extensively related to atherosclerotic lesion development while oxidative modifications confer the particle pro-atherogenic features. Herein, we reviewed the oxidation versus nitration of human LDL protein and lipid fractions. We propose that unsaturated fatty acids present in LDL can be nitrated under mild nitration conditions, suggesting an anti-atherogenic role for LDL carrying nitro-fatty acids (NFA).

中文翻译：

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人低密度脂蛋白中的脂肪酸硝化作用。

脂质硝化作用发生在生理和病理生理状况期间，产生了多种能够调节炎症细胞反应的生物分子。低密度脂蛋白（LDL）的氧化与动脉粥样硬化病变的发展密切相关，而氧化修饰赋予颗粒促动脉粥样硬化的特征。本文中，我们综述了人LDL蛋白和脂质组分的氧化与硝化作用。我们建议可以在温和的硝化条件下将LDL中存在的不饱和脂肪酸硝化，这表明LDL携带硝基脂肪酸（NFA）具有抗动脉粥样硬化的作用。