OBJECTIVE Impairment of basal ganglia (BG)-thalamo-cortical circuit causes various symptoms of Parkinson's disease (PD). We investigated the functional connectivity (FC) patterns of putamen among PD subtypes and healthy control (HC) and explored their clinical significance. METHODS A total of 16 patients with tremor-dominant (TD) PD, 23 patients with postural instability and gait difficulty-dominant (PIGD) PD, and 31 HC that underwent functional magnetic resonance imaging were observed. Voxel-wise FC analysis was performed by computing correlation between bilateral putamen and other voxels within the brain. Correlation analysis was performed between FC strength and clinical symptoms. RESULTS Compared with PIGD group, TD group showed increased FC between left putamen and right cerebellum lobule VI and cerebellum crus I, then we compared the cerebellum FC difference among the three groups. The cerebellum lobule VI FC difference was mainly involved in motor related cortex, and the cerebellum crus I FC difference was related to cognition areas. While compared with HC, TD and PIGD groups both had significant FC difference brain areas correlated with motor and cognition symptoms. The connectively of putamen and right cerebellum lobules VI and I showed positive correlation with tremor and Montreal Cognitive Assessment degree of scores, respectively. The connectivity of putamen and sensorimotor cortex had negative correlation with PIGD scores. CONCLUSIONS The altered connectivity of BG-cortical circuit in patients with PD was related to PIGD symptoms. Motor and cognitive impairments declined slower in patients with TD PD, which may be related to increased functional connectivity between putamen and cerebellum.

中文翻译：

---

帕金森氏病不同亚型之间的壳核和小脑连接性改变。

目的基底神经节（BG）-丘脑-皮质回路受损会导致帕金森氏病（PD）的各种症状。我们调查了PD亚型和健康对照（HC）之间的壳聚糖功能连接（FC）模式，并探讨了它们的临床意义。方法总共观察16例震颤为主的TD患者，23例姿势不稳且以步态困难为主的PD患者以及31例行功能磁共振成像的HC。通过计算双侧壳壳蛋白与大脑内其他体素之间的相关性，进行体素智能FC分析。FC强度与临床症状之间进行了相关分析。结果与PIGD组相比，TD组显示左壳核与右小脑小叶VI和小脑I之间的FC增加，然后我们比较了三组之间的小脑FC差异。小脑小叶VI FC差异主要与运动相关皮层有关，小脑小腿I FC差异与认知区域有关。与HC相比，TD和PIGD组均具有明显的FC差异大脑区域，与运动和认知症状相关。壳核和右小脑小叶VI和I的结缔组织分别与震颤和蒙特利尔认知评估得分呈正相关。壳核和感觉运动皮层的连通性与PIGD评分呈负相关。结论PD患者BG皮质回路的连接性改变与PIGD症状有关。TD PD患者的运动和认知障碍下降较慢，