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Update of inflammasome activation in microglia/macrophage in aging and aging-related disease.
CNS Neuroscience & Therapeutics ( IF 5.5 ) Pub Date : 2019-11-14 , DOI: 10.1111/cns.13262 Meng-Yan Hu 1 , Yin-Yao Lin 1 , Bing-Jun Zhang 1 , Dan-Li Lu 1 , Zheng-Qi Lu 1 , Wei Cai 1, 2
CNS Neuroscience & Therapeutics ( IF 5.5 ) Pub Date : 2019-11-14 , DOI: 10.1111/cns.13262 Meng-Yan Hu 1 , Yin-Yao Lin 1 , Bing-Jun Zhang 1 , Dan-Li Lu 1 , Zheng-Qi Lu 1 , Wei Cai 1, 2
Affiliation
Aging and aging-related CNS diseases are associated with inflammatory status. As an efficient amplifier of immune responses, inflammasome is activated and played detrimental role in aging and aging-related CNS diseases. Macrophage and microglia display robust inflammasome activation in infectious and sterile inflammation. This review discussed the impact of inflammasome activation in microglia/macrophage on senescence "inflammaging" and aging-related CNS diseases. The preventive or therapeutic effects of targeting inflammasome on retarding aging process or tackling aging-related diseases are also discussed.
中文翻译:
衰老和衰老相关疾病中小胶质细胞/巨噬细胞中炎性体激活的更新。
与衰老和衰老相关的中枢神经系统疾病与炎症状态有关。作为有效的免疫应答放大剂,炎症小体被激活并在衰老和与衰老相关的中枢神经系统疾病中起有害作用。巨噬细胞和小胶质细胞在感染性和无菌性炎症中显示出强大的炎症小体激活。这篇综述讨论了小胶质细胞/巨噬细胞中的炎性体活化对衰老“发炎”和与衰老相关的中枢神经系统疾病的影响。还讨论了靶向炎性体对延缓衰老过程或应对衰老相关疾病的预防或治疗作用。
更新日期:2019-11-15
中文翻译:
衰老和衰老相关疾病中小胶质细胞/巨噬细胞中炎性体激活的更新。
与衰老和衰老相关的中枢神经系统疾病与炎症状态有关。作为有效的免疫应答放大剂,炎症小体被激活并在衰老和与衰老相关的中枢神经系统疾病中起有害作用。巨噬细胞和小胶质细胞在感染性和无菌性炎症中显示出强大的炎症小体激活。这篇综述讨论了小胶质细胞/巨噬细胞中的炎性体活化对衰老“发炎”和与衰老相关的中枢神经系统疾病的影响。还讨论了靶向炎性体对延缓衰老过程或应对衰老相关疾病的预防或治疗作用。