Multiple genes have been implicated in Parkinson's disease (PD), including causal gene variants and risk variants typically identified using genome-wide association studies. Variants in the alcohol dehydrogenase genes ADH1C and ADH1B are among the genes that have been associated with PD, suggesting that this family of genes may be important in PD. As part of the International Parkinson's Disease Genomics Consortium's efforts to scrutinize previously reported risk factors for PD, we explored genetic variation in the alcohol dehydrogenase genes ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, and ADH7 using imputed genome-wide association study data from 15,097 cases and 17,337 healthy controls. Rare-variant association tests and single-variant score tests did not show any statistically significant association of alcohol dehydrogenase genetic variation with the risk for PD.

中文翻译：

---

没有遗传证据表明酒精脱氢酶基因与帕金森病风险有关

帕金森病 (PD) 涉及多个基因，包括通常使用全基因组关联研究确定的因果基因变异和风险变异。酒精脱氢酶基因 ADH1C 和 ADH1B 的变体是与 PD 相关的基因之一，这表明该基因家族可能在 PD 中很重要。作为国际帕金森病基因组学联盟仔细审查先前报告的 PD 风险因素的努力的一部分，我们使用估算的全基因组关联研究数据探索了酒精脱氢酶基因 ADH1A、ADH1B、ADH1C、ADH4、ADH5、ADH6 和 ADH7 的遗传变异来自 15,097 例病例和 17,337 名健康对照者。