The mechanisms mediating the repair of DNA damage in human cells have been the focus of a multitude of studies since the middle of the previous century, and many of the proteins implicated in these processes have been identified as being part of large macromolecular assemblies. This review gives an overview of the current knowledge of protein structures specifically involved in the repair of DNA double strand breaks through Non-Homologous End Joining, with a focus on recent structures obtained via cryo-electron microscopy and prospects for how this rapidly evolving method will impact our understanding of DNA repair.

中文翻译：

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通过非同源末端连接进行DNA双链断裂修复中的多组分装配体的结构生物学。

自上世纪中叶以来，介导人类细胞中DNA损伤修复的机制一直是众多研究的重点，并且与这些过程有关的许多蛋白质已被鉴定为大分子组装体的一部分。这篇综述概述了通过非同源末端连接特别涉及DNA双链断裂修复的蛋白质结构的当前知识，重点介绍了通过冷冻电子显微镜获得的最新结构以及这种快速发展的方法将如何发展的前景。影响我们对DNA修复的理解。