The clinical pathogenesis of multiple sclerosis (MS) can be profoundly deleterious to employment, with disability and fatigue leading to reduced employment hours, changes to less demanding job tasks, and early retirement.1 Given the typical onset of MS in the 20–40 years old range, these effects on employment occur in the prime years when people are typically establishing their careers. MS clinical progression leads directly to reduced or lost income and forced patients to rely on disability pension supports, and thus becoming a significant cost for society. Until recently, treatment options to reduce MS progression were limited. Symptom-specific treatments could ameliorate some elements like spasticity, incontinence and fatigue but did …

中文翻译：

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通过有效的治疗，将MS患者留在员工队伍中。

多发性硬化症（MS）的临床发病机理可能会对就业产生极大的损害，残疾和疲劳会导致就业时间减少，工作要求不高的变化以及提前退休。1鉴于20-40年内MS的典型发作在较旧的范围内，这些对就业的影响发生在人们通常建立职业的黄金时期。MS的临床进展直接导致收入减少或损失，并迫使患者依靠残疾抚恤金支持，因此成为社会的重大费用。直到最近，减少MS进展的治疗方案仍然有限。症状特定的治疗可以改善某些症状，例如痉挛，大小便失禁和疲劳，但确实……