BACKGROUNDS Reliable non-invasive methods for measuring body temperature are essential for the diagnosis and monitoring of infectious disease. METHODS This study used Intraclass Correlation Coefficients (ICC) and the Bland- Altman plot to analyse the agreement between temperature measurements using an ingestible capsule sensor, a skin sensor and two non-invasive peripheral temperature measurements (axillary and infrared non-contact), collected from a population of febrile patient admitted for infectious disease. RESULTS Of the 77 febrile patients screened, 26 patients were enrolled. The ICC between axillary temperature measurements (Taxi) vs. non-contact measurements (Tno-c) were 0.34 [-0.18; 0.63], 0.87 [0.55; 0.94] between Taxi vs. ingestible capsule measurements (Tcap) and 0.12 [-0.09; 0.37] between Taxi vs. Tetac. The mean difference between Taxi vs Tno-c was -1.18 °C with limits of agreement (LoA) from -2.96 to 0.58 °C. The mean difference between Taxi vs Tcap was 0.48 °C, with LoA from -0.60 to 1.56 °C. The mean difference between Taxi vs Tetac was -4.23 °C with LoA from -7.22 to -1.23 °C. CONCLUSIONS Ingestible capsule measurements are reliable enough to adequately estimate the core body temperature in clinical practice. Its non-invasiveness, and the real-time remote control offer new opportunities for future research into fever during infectious diseases.

中文翻译：

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可摄入的传感器与高热患者的周围温度测量密切相关。

背景技术可靠的无创测量体温的方法对于诊断和监测传染病至关重要。方法本研究使用类内相关系数（ICC）和Bland-Altman图分析了使用可摄入胶囊传感器，皮肤传感器和两个非侵入性外周温度测量值（腋窝和红外非接触式）收集的温度测量值之间的一致性来自因感染而入院的高热患者人群。结果在筛选的77例高热患者中，有26例入选。腋窝温度测量值（Taxi）与非接触测量值（Tno-c）之间的ICC为0.34 [-0.18；0.63]，0.87 [0.55; 出租车与可摄取胶囊的测量值（Tcap）之间的差值为0.92和0.12 [-0.09; 0.37]的士与Tetac之间。出租车与Tno-c之间的平均差异为-1.18°C，一致极限（LoA）为-2.96至0.58°C。出租车与Tcap的平均差为0.48°C，LoA为-0.60至1.56°C。出租车与Tetac之间的平均差为-4.23°C，LoA为-7.22至-1.23°C。结论可摄取胶囊的测量结果足够可靠，足以在临床实践中充分估计核心体温。它的无创性和实时远程控制为传染病期间发烧的未来研究提供了新的机会。结论可摄取胶囊的测量结果足够可靠，足以在临床实践中充分估计核心体温。它的无创性和实时远程控制为传染病期间发烧的未来研究提供了新的机会。结论可摄取胶囊的测量结果足够可靠，足以在临床实践中充分估计核心体温。它的无创性和实时远程控制为传染病期间发烧的未来研究提供了新的机会。