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Synthesis of Brush-Like Glycopolymers with Monodisperse, Sequence-Defined Side Chains and Their Interactions with Plant and Animal Lectins.
Macromolecular Rapid Communications ( IF 4.6 ) Pub Date : 2019-11-13 , DOI: 10.1002/marc.201900459
Fadi Shamout 1 , Alessandra Monaco 2 , Gokhan Yilmaz 3 , Caglar Remzi Becer 2 , Laura Hartmann 1
Affiliation  

The synthesis of brush glycopolymers mimicking the architecture of proteoglycans is achieved by grafting sequence-defined glycooligomers derived from solid-phase polymer synthesis onto a poly(active ester) scaffold. This approach gives access to a first library of brush glycopolymers with controlled variations in the degree of branching and number of carbohydrate ligands per branch. When studying lectin binding of linear and brush glycopolymers to lectins Concanavalin A (ConA), dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), and mannose-binding lectin (MBL), different preferences are observed with MBL showing higher binding to linear glycopolymer and ConA and DC-SIGN favoring brush glycopolymers. This finding suggests that the architecture of polymeric glycan mimetics affects binding to lectins not only in terms of creating higher avidity but potentially also selectivity ligands.

中文翻译:

具有单分散,序列确定的侧链的类似刷子的糖共聚物的合成及其与植物和动物凝集素的相互作用。

通过将衍生自固相聚合物合成的序列定义的糖低聚物接枝到聚(活性酯)支架上来实现模拟蛋白聚糖结构的刷糖聚合物的合成。这种方法可以访问第一个刷糖聚合物库,其支化程度和每个分支的碳水化合物配体数量具有受控的变化。在研究线性和刷式糖聚合物与凝集素伴刀豆球蛋白A(ConA),树突状细胞特异性细胞间粘附分子3-吸附非整联蛋白(DC-SIGN)和甘露糖结合凝集素(MBL)的凝集素结合时,观察到了不同的偏好MBL与线性糖聚合物的结合更高,而ConA和DC-SIGN则有利于刷糖聚合物。
更新日期:2019-11-13
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