BACKGROUND Iron plays a critical role in normal brain functions and development, but it has also been known to have adverse neurological effects. METHODS Here, we investigated the associations of iron levels in hair with regional gray matter volume (rGMV), regional cerebral blood flow (rCBF), fractional anisotropy (FA), mean diffusivity (MD), and cognitive differences in a study cohort of 590 healthy young adults. RESULTS Our findings showed that high iron levels were associated with lower rGMV in areas including the hippocampus, lower rCBF in the anterior and posterior parts of the brain, greater FA in areas including the part of the splenium of the corpus callosum, lower MD in the overlapping area including the splenium of the corpus callosum, as well as greater MD in the left hippocampus and areas including the frontal lobe. CONCLUSION These results are compatible with the notion that iron plays diverse roles in neural mechanisms in healthy young adults.

中文翻译：

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年轻人中头发中铁水平与大脑结构和功能的关联。

背景技术铁在正常的脑功能和发育中起关键作用，但是还已知其具有不利的神经学作用。方法在590名研究人群中，我们调查了头发中铁水平与局部灰质体积（rGMV），局部脑血流量（rCBF），分数各向异性（FA），平均扩散率（MD）和认知差异之间的关系。健康的年轻成年人。结果我们的研究结果表明，高铁水平与包括海马区在内的rGMV降低，大脑前部和后部rCBF较低，call体脾部分包括FA较高，MD较低有关。包括area体脾脏在内的重叠区域，以及左侧海马和额叶等区域的更大的MD。