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Association of circulating selenium concentration with dyslipidemia: Results from the NHANES.
Journal of Trace Elements in Medicine and Biology ( IF 3.5 ) Pub Date : 2019-11-13 , DOI: 10.1016/j.jtemb.2019.126438
Yu-Qing Huang 1 , Geng Shen 1 , Kenneth Lo 2 , Jia-Yi Huang 1 , Lin Liu 1 , Chao-Lei Chen 1 , Yu-Ling Yu 1 , Shuo Sun 1 , Bin Zhang 1 , Ying-Qing Feng 1
Affiliation  

BACKGROUND Observational studies have suggested that selenium levels might associate with the risk of cardio-metabolic diseases, but how circulating selenium is related to dyslipidemia remains inconclusive. OBJECTIVES To investigate the association of circulating selenium levels with lipid profiles and dyslipidemia among US adults. METHODS Using the data collected from the National Health and Nutrition Examination Survey (NHANES 1999-2006), we performed multivariate logistic regression to examine the association of circulating selenium levels (in quartiles) with total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, and atherogenic index (AI). RESULTS We included 2903 adults (49.3 % male) (average age: 61.9) for analysis. Circulating selenium had non-linear association with TC, LDL-C, HDL-C, and AI (all p < 0.05). When comparing with the lowest quartile, subjects with the highest quartile of circulating selenium (>147.00 μg/L) had the higher odds of elevated TG (OR: 1.75, 95% CI = 1.14, 2.68), TC (OR: 2.47, 95% CI = 1.62, 3.76), LDL-C (OR: 2.52, 95% CI = 1.60, 3.96), non-HDL-C (OR: 2.17, 95% CI = 1.41, 3.33), AI (OR: 1.20, 95% CI = 0.73, 1.97) and low-HDL-C (OR: 2.10, 95% CI = 1.19, 3.72). Similar patterns were observed in subgroup analysis. CONCLUSIONS Higher circulating selenium levels had non-linear association with lipid profiles and the increased odds of dyslipidemia.

中文翻译:

循环中硒浓度与血脂异常的关系:NHANES的结果。

背景技术观察性研究表明,硒水平可能与心血管疾病的风险有关,但是循环硒与血脂异常的关系尚无定论。目的探讨美国成年人中循环硒水平与血脂和血脂异常的关系。方法使用从美国国家健康和营养调查(NHANES 1999-2006)中收集的数据,我们进行了多因素logistic回归分析,以研究循环硒水平(四分位数)与总胆固醇(TC),甘油三酸酯(TG),低胆固醇的关系。高密度脂蛋白胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C),非HDL-C和动脉粥样硬化指数(AI)。结果我们纳入了2903名成人(男性占49.3%)(平均年龄:61.9)进行分析。循环硒与TC,LDL-C,HDL-C和AI呈非线性关系(所有p <0.05)。与最低四分位数比较时,循环硒四分位数最高(> 147.00μg/ L)的受试者发生TG(OR:1.75,95%CI = 1.14,2.68),TC(OR:2.47,95)的几率更高%CI = 1.62,3.76),LDL-C(OR:2.52,95%CI = 1.60,3.96),非HDL-C(OR:2.17,95%CI = 1.41,3.33),AI(OR:1.20, 95%CI = 0.73,1.97)和低HDL-C(OR:2.10,95%CI = 1.19,3.72)。在亚组分析中观察到相似的模式。结论较高的循环硒水平与血脂谱和血脂异常几率呈非线性关系。00μg/ L)发生TG(OR:1.75,95%CI = 1.14,2.68),TC(OR:2.47,95%CI = 1.62,3.76),LDL-C(OR:2.52,95)的几率更高%CI = 1.60,3.96),非HDL-C(OR:2.17,95%CI = 1.41,3.33),AI(OR:1.20,95%CI = 0.73,1.97)和低HDL-C(OR: 2.10,95%CI = 1.19,3.72)。在亚组分析中观察到相似的模式。结论较高的循环硒水平与血脂谱和血脂异常几率呈非线性关系。00μg/ L)发生TG(OR:1.75,95%CI = 1.14,2.68),TC(OR:2.47,95%CI = 1.62,3.76),LDL-C(OR:2.52,95)的几率更高%CI = 1.60,3.96),非HDL-C(OR:2.17,95%CI = 1.41,3.33),AI(OR:1.20,95%CI = 0.73,1.97)和低HDL-C(OR: 2.10,95%CI = 1.19,3.72)。在亚组分析中观察到相似的模式。结论较高的循环硒水平与血脂谱和血脂异常几率呈非线性关系。
更新日期:2019-11-13
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