NRF2 is a redox-sensitive transcription factor that plays an important role in protecting organisms against diverse types of electrophiles or oxidants. The level of NRF2 is maintained low in normal cells, but highly elevated in cancer provoking chemoresistance or radioresistance. It is now recognized that NRF2 does not merely maintain the redox balance, but also plays significant roles in autophagy, apoptosis, cell cycle progression, and stem cell differentiation, all of which could be possibly attributable to the existence of multiple binding proteins. In the present manuscript, we summarize direct binding partners of NRF2 and illustrate how they bind to NRF2 and regulate its stability or activity.

NRF2是氧化还原敏感的转录因子，在保护生物免受各种类型的亲电试剂或氧化剂的侵害中起着重要作用。NRF2的水平在正常细胞中保持较低水平，但在癌症中高度升高，从而引起化学抗性或放射抗性。现在已经认识到，NRF2不仅保持氧化还原平衡，而且在自噬，细胞凋亡，细胞周期进程和干细胞分化中起重要作用，所有这些都可能归因于多种结合蛋白的存在。在本手稿中，我们总结了NRF2的直接结合伴侣，并说明了它们如何与NRF2结合并调节其稳定性或活性。