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Tissue Repair Brakes: A Common Paradigm in the Biology of Regeneration
STEM CELLS ( IF 5.2 ) Pub Date : 2019-11-28 , DOI: 10.1002/stem.3118
Valentina Cigliola 1 , Luiza Ghila 2 , Simona Chera 2 , Pedro L Herrera 3
Affiliation  

To date, most attention on tissue regeneration has focused on the exploration of positive cues promoting or allowing the engagement of natural cellular restoration upon injury. In contrast, the signals fostering cell identity maintenance in the vertebrate body have been poorly investigated; yet they are crucial, for their counteraction could become a powerful method to induce and modulate regeneration. Here we review the mechanisms inhibiting pro‐regenerative spontaneous adaptive cell responses in different model organisms and organs. The pharmacological or genetic/epigenetic modulation of such regenerative brakes could release a dormant but innate adaptive competence of certain cell types and therefore boost tissue regeneration in different situations.

中文翻译:

组织修复制动器:再生生物学中的常见范式

迄今为止,对组织再生的大多数关注都集中在探索促进或允许在损伤时进行自然细胞修复的积极线索。相比之下,在脊椎动物体内促进细胞身份维持的信号却没有得到很好的研究。然而它们是至关重要的,因为它们的反作用可能成为诱导和调节再生的有力方法。在这里,我们回顾了在不同模式生物和器官中抑制促再生自发适应性细胞反应的机制。这种再生制动的药理学或遗传/表观遗传调节可以释放某些细胞类型的休眠但先天的适应性能力,从而在不同情况下促进组织再生。
更新日期:2019-11-28
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