High blood pressure (BP) variability is associated with the increased risk of cardiovascular and renal damage together with increased cardiovascular mortality. The aim of our study was to investigate the relationship between BP variability and subclinical target organ damage (TOD) in patients with controlled essential hypertension. One hundred patients with controlled essential hypertension were randomly selected from outpatient clinic of Beni-Suef University hospital. All patients were subjected to full history taking, physical examination, three separate office BP measurements for assessment of long-term BP variability, ambulatory BP monitoring for short-term variability, and finally different investigations for subclinical TOD. We had 73 patients with subclinical TOD. Long-term visit-to-visit variability was evaluated by measuring SD (standard deviation) and CV (coefficient of variance) of systolic and diastolic BP. None of the parameters of long-term BP variability were significantly higher among patients with TOD compared with those without TOD. For short-term variability evaluated by ambulatory BP monitoring, average real variability (ARV) was the only parameter that had a significant consistent association with TOD in contrast to SD and CV. Finally, Daytime systolic ARV, nighttime diastolic ARV, and age were independent predictors of TOD (P values = 0.014, 0.018, 0.047, and 0.02, respectively). We concluded that ARV could be an appropriate index of BP variability and a more useful predictor of TOD in contrast to other parameters of BP variability

高血压 (BP) 变异性与心血管和肾脏损害风险增加以及心血管死亡率增加有关。我们研究的目的是调查血压变异性与控制的原发性高血压患者亚临床靶器官损伤 (TOD) 之间的关系。从 Beni-Suef 大学医院门诊随机抽取 100 名控制的原发性高血压患者。所有患者均接受完整的病史采集、体格检查、三个独立的诊室血压测量以评估长期血压变异性、动态血压监测以监测短期变异性，最后对亚临床 TOD 进行不同的调查。我们有 73 名亚临床 TOD 患者。通过测量收缩压和舒张压的 SD（标准偏差）和 CV（方差系数）来评估长期访问到访问的可变性。与没有 TOD 的患者相比，TOD 患者的长期血压变异性参数没有一个显着升高。对于动态血压监测评估的短期变异性，与 SD 和 CV 相比，平均真实变异性 (ARV) 是唯一与 TOD 具有显着一致关联的参数。最后，白天收缩期 ARV、夜间舒张期 ARV 和年龄是 TOD 的独立预测因子。与 SD 和 CV 相比，平均真实变异性 (ARV) 是唯一与 TOD 显着一致关联的参数。最后，白天收缩期 ARV、夜间舒张期 ARV 和年龄是 TOD 的独立预测因子。与 SD 和 CV 相比，平均真实变异性 (ARV) 是唯一与 TOD 显着一致关联的参数。最后，白天收缩期 ARV、夜间舒张期 ARV 和年龄是 TOD 的独立预测因子。P值分别 = 0.014、0.018、0.047 和 0.02）。我们得出的结论是，与其他血压变异性参数相比，ARV 可能是一个适当的血压变异性指标和更有用的 TOD 预测指标