Mounting evidence supports the central role of oxidative stress and inflammation in obesity and the development of hypertension. However, most studies focusing on the non-enzymatic antioxidants, such as uric acid and bilirubin, and their relationship with obesity and hypertension were done in older populations with overt cardiovascular disease. The aim of this study was therefore to compare measures of cardiovascular function (blood pressure and arterial stiffness) and non-enzymatic antioxidants (uric acid and bilirubin) between young healthy lean and overweight/obese men and women and to investigate the link between these variables. We grouped 967 men and women (aged 20–30 years) according to body mass index (BMI) categories (lean BMI < 25 kg/m²; overweight/obese BMI ≥ 25 kg/m²). Cardiovascular measurements included 24 h blood pressure and carotid-femoral pulse wave velocity. Serum samples were used to analyse uric acid and bilirubin. Women and men with a BMI ≥ 25 kg/m² displayed higher 24 h blood pressure (P < 0.001) and uric acid (P ≤ 0.014) than their lean counterparts; lean women showed higher bilirubin (P < 0.001). In multi-variable adjusted regression analyses we found that 24 h systolic blood pressure was independently associated with uric acid (R² = 0.10; β = 0.19; P = 0.017) only in overweight/obese women. In lean women a negative association of 24 h systolic blood pressure with bilirubin (R² = 0.03; β = −0.14; P = 0.018) was found. No associations were found in men. In conclusion, we found adverse associations between blood pressure and uric acid in young healthy women with increased adiposity, but not in lean women or men.

越来越多的证据支持氧化应激和炎症在肥胖和高血压发展中的核心作用。然而，大多数关注非酶抗氧化剂（如尿酸和胆红素）及其与肥胖和高血压关系的研究都是在患有明显心血管疾病的老年人群中进行的。因此，本研究的目的是比较年轻健康的瘦人和超重/肥胖男性和女性之间心血管功能（血压和动脉僵硬度）和非酶抗氧化剂（尿酸和胆红素）的测量值，并调查这些变量之间的联系. 我们根据体重指数 (BMI) 类别（瘦 BMI < 25 kg/m ²；超重/肥胖 BMI ≥ 25 kg/m ²）对 967 名男性和女性（20-30 岁）进行分组）。心血管测量包括 24 小时血压和颈股脉搏波速度。血清样品用于分析尿酸和胆红素。BMI ≥ 25 kg/m ^{2 的}女性和男性的24 小时血压 ( P  < 0.001) 和尿酸 ( P  ≤ 0.014) 高于瘦人；瘦女性表现出更高的胆红素（P  < 0.001）。在多变量调整回归分析中，我们发现 仅在超重/肥胖女性中，24 小时收缩压与尿酸独立相关（R ²  = 0.10；β  = 0.19；P = 0.017）。在瘦女性中，24 小时收缩压与胆红素呈负相关（R²  = 0.03；β  = -0.14； 发现P = 0.018)。在男性中没有发现关联。总之，我们发现肥胖增加的年轻健康女性的血压和尿酸之间存在不利关联，但在瘦女性或男性中则没有。