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Copper-catalyzed tandem cyclization and vinylation for the synthesis of 2-trifluoromethyl benzofurans
Journal of Fluorine Chemistry ( IF 1.9 ) Pub Date : 2019-11-12 , DOI: 10.1016/j.jfluchem.2019.109418
Shi-Yu He , Jing Xiong , Bo-Lun Hu , Xing-Guo Zhang

A copper-catalyzed tandem cyclization and vinylation of 2-chloro-1-(2-bromoaryl)-3,3,3-trifluoropropenes with KOH has been developed for the synthesis of 2-trifluoromethyl benzofuran derivatives. The reaction involves dual CO bonds formation and hydroarylation of aryl trifluoropropynes. This approach represents a simple and efficient one-pot synthesis of 2-trifluoromethy-3-vinylbenzofurans, which are potentially useful in drug design.



中文翻译:

铜催化串联环化和乙烯基化合成2-三氟甲基苯并呋喃

铜催化串联环化和2-氯-1-(2-溴芳基)-3,3,3-三氟丙烯与KOH的乙烯基化反应已被开发出来,用于合成2-三氟甲基苯并呋喃衍生物。该反应涉及双C O键的形成和芳基三氟丙炔的氢芳基化。这种方法代表了一种简单而有效的一锅合成2-三氟甲基-3-乙烯基苯并呋喃的方法,该方法可能在药物设计中有用。

更新日期:2019-11-13
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