Seven undescribed polyketides javanicols A-E, 5-epi-citreoviridin and 5-epi-isocitreoviridin, together with five known compounds, were isolated from the endolichenic fungus Eupenicillium javanicum. The structures of these polyketides were determined by means of extensive spectroscopic analyses, electronic circular dichroism (ECD) calculations and gauge-independent atomic orbital (GIAO) NMR shift calculations. These compounds were evaluated for potential anti-inflammatory activity against LPS-activated RAW 264.7 cells. Javanicol E and (+)-terrein displayed moderate inhibitory effects on NO production, with IC50 values of 17.00 and 13.46 μM, respectively.

中文翻译：

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来自内生真菌 Eupenicillium javanicum 的聚酮化合物及其抗炎活性

七个未描述的聚酮类 javanicols AE、5-epi-citreoviridin 和 5-epi-isocitreoviridin，连同五种已知的化合物，从内源性真菌 Eupenicillium javanicum 中分离出来。这些聚酮化合物的结构是通过广泛的光谱分析、电子圆二色性 (ECD) 计算和与规范无关的原子轨道 (GIAO) NMR 位移计算确定的。评估了这些化合物对 LPS 激活的 RAW 264.7 细胞的潜在抗炎活性。Javanicol E 和 (+)-terrein 对 NO 产生显示出中等抑制作用，IC50 值分别为 17.00 和 13.46 μM。