Complex natural products bearing strained cyclobutane subunits, including terpenoids, alkaloids and steroids, not only display fascinating architectures, but also show potent biological activities. Due to their unique structures as critical core skeletons in these molecules, a variety of new strategies for the construction of cyclobutane rings have greatly emerged during the last decade. In this review, we wish to summarize the recent progress in the cyclobutane-containing natural product synthesis with an emphasis on disconnection tactics employed to forge the four-membered rings, aiming to provide a complement to existing reviews.

中文翻译：

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含环丁烷天然产物全合成的最新进展

带有应变环丁烷亚基（包括萜类，生物碱和类固醇）的复杂天然产物不仅显示出迷人的结构，而且还显示出强大的生物活性。由于它们作为这些分子中关键的核心骨架的独特结构，在过去的十年中，出现了许多新的构建环丁烷环的新策略。在本综述中，我们希望总结含环丁烷天然产物合成的最新进展，重点是用于锻造四元环的断开策略，旨在为现有综述提供补充。