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Elevated levels of circulating invariant natural killer cell subsets are skewed toward Th2-like phenotype in children with sickle cell disease.
Clinical Immunology ( IF 8.6 ) Pub Date : 2019-11-11 , DOI: 10.1016/j.clim.2019.108308
Mohamed-Rachid Boulassel 1 , Abeer Al-Zubaidi 1 , Shoaib Al-Zadjali 2 , Zahra Al-Qarni 1 , Nidaa Al-Naamany 1 , Ahmed Al-Yarabi 3 , Mohamed Elshinawy 4 , Yasser Wali 5
Affiliation  

Invariant natural killer T (iNKT) cells are being considered as potential targets for immunotherapeutic strategies in a variety of conditions including sickle cell disease (SCD). However, relatively little is known about the fate of iNKT cell subsets in children with SCD. Herein, quantitative and qualitative analyses of circulating iNKT cell subsets were carried out in 120 children in steady state and 30 healthy controls. Children with SCD displayed significantly elevated levels of circulating iNKT cell subsets with a preferential polarization toward Th2-like cells. The known SCD modifiers did not influence levels of iNKT cell subsets, except that children carrying the Bantu haplotype exhibited elevated levels of CD4iNKT cells, and to a lesser degree CD8iNKT cells. Collectively, these findings indicate that circulating iNKT cell subsets are significantly increased in children with SCD, and highlight the existence of imbalanced production of cytokines toward Th2-like phenotype, which seems to be associated with genetic polymorphisms.

中文翻译:

镰状细胞病患儿的循环不变自然杀伤细胞亚群水平升高偏向Th2样表型。

在包括镰状细胞病(SCD)在内的各种情况下,不变的自然杀伤T(iNKT)细胞被视为免疫治疗策略的潜在靶标。然而,对SCD儿童的iNKT细胞亚群的命运知之甚少。在本文中,对120例处于稳态的儿童和30例健康对照者进行了循环iNKT细胞亚群的定量和定性分析。患有SCD的儿童显示出循环iNKT细胞亚群的水平显着升高,并且对Th2样细胞具有优先极化。已知的SCD修饰剂不影响iNKT细胞亚群的水平,除了携带班图单体型的儿童表现出较高水平的CD4iNKT细胞和较低程度的CD8iNKT细胞。总的来说,
更新日期:2019-11-11
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