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Bioinspired tough, conductive hydrogels with thermally reversible adhesiveness based on nanoclay confined NIPAM polymerization and a dopamine modified polypeptide
Materials Chemistry Frontiers ( IF 7 ) Pub Date : 2019-11-12 , DOI: 10.1039/c9qm00582j
Xiang Di 1, 2, 3, 4, 5 , Chen Hang 1, 2, 3, 4, 5 , Yue Xu 1, 2, 3, 4, 5 , Qiyue Ma 1, 2, 3, 4, 5 , Feifan Li 1, 2, 3, 4, 5 , Pingchuan Sun 1, 2, 3, 4, 5 , Guolin Wu 1, 2, 3, 4, 5
Affiliation  

Hydrogels with excellent conductivity and flexibility have a wide range of applications in the biomedical field, such as in wearable devices, soft electronic skins, and biosensors. Inspired by marine mussels, a biocompatible hydrogel with controllable adhesiveness and a wearable strain-sensor were successfully prepared by polymerization of N-isopropylacrylamide (NIPAM) and a dopamine-modified polypeptide (PDAEA). The PNIPAM-clay-PDAEA hydrogel displayed repeatable and controllable adhesiveness due to the presence of free catechol groups in the PDAEA chains and the intrinsic thermo-sensitivity of the PNIPAM-based hydrogel. These materials also exhibited outstanding strain and pressure sensitive conductivity, which could be ascribed to a sufficient number of free moving ions in the hydrogel system. Test results showed that these conductive hydrogels possessed excellent biocompatibility, stable drug release behavior, and improved cell proliferation. Therefore, the as-prepared nanocomposite hydrogel has great potential applications as a wearable soft electronic skin and in tissue engineering.

中文翻译:

基于纳米粘土限制的NIPAM聚合和多巴胺修饰的多肽,具有生物可逆的具有热可逆粘合性的坚韧,导电水凝胶

具有出色导电性和柔韧性的水凝胶在生物医学领域具有广泛的应用,例如在可穿戴设备,柔软的电子皮肤和生物传感器中。在海洋贻贝的启发下,通过N的聚合成功制备了具有可控粘合性的生物相容性水凝胶和可穿戴应变传感器。-异丙基丙烯酰胺(NIPAM)和多巴胺修饰的多肽(PDAEA)。由于PDAEA链中存在游离邻苯二酚基团以及基于PNIPAM的水凝胶固有的热敏性,PNIPAM-粘土-PDAEA水凝胶显示出可重复和可控的粘合性。这些材料还表现出出色的应变和压敏电导率,这可归因于水凝胶系统中足够数量的自由移动离子。测试结果表明,这些导电水凝胶具有出色的生物相容性,稳定的药物释放性能和改善的细胞增殖能力。因此,制备的纳米复合水凝胶作为可穿戴的柔软电子皮肤和组织工程具有巨大的潜在应用。
更新日期:2019-11-12
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