Spermatogenesis is supported by intricate crosstalk between Sertoli cells and germ cells including spermatogonia, spermatocytes, haploid spermatids, and spermatozoa, which takes place in the epithelium of seminiferous tubules. Sertoli cells, also known as 'mother' or 'nurse' cells, provide nutrients, paracrine factors, cytokines, and other biomolecules to support germ cell development. Sertoli cells facilitate the generation of several biologically active peptides, which include F5-, noncollagenous 1 (NC1)-, and laminin globular (LG)3/4/5-peptide, to modulate cellular events across the epithelium. Here, we critically evaluate the involvement of these peptides in facilitating crosstalk between Sertoli and germ cells to support spermatogenesis and thus fertility. Modulating or mimicking the activity of F5-, NC1-, and LG3/4/5-peptide could be used to enhance the transport across the blood-testis barrier (BTB) of contraceptive drugs or to treat male infertility.

中文翻译：

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男性生殖力中睾丸支持细胞与生殖细胞之间的串扰。

睾丸支持细胞与包括精原细胞，精子细胞，单倍体精子和精子在内的生殖细胞之间的错综复杂的串扰支持了精子的发生，这种情况发生在生精小管的上皮细胞中。睾丸支持细胞，也称为“母亲”或“护士”细胞，提供营养，旁分泌因子，细胞因子和其他生物分子来支持生殖细胞的发育。睾丸支持细胞促进几种生物活性肽的生成，包括F5-，非胶原1（NC1）-和层粘连蛋白球状（LG）3/4 / 5-肽，以调节整个上皮细胞的事件。在这里，我们批判性地评估这些肽在促进支持细胞和生殖细胞之间的串扰以支持精子发生从而促进生育方面的参与。调节或模仿F5-，NC1-，