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Safer-by-design biocides made of tri-thiol bridged silver nanoparticle assemblies.
Nanoscale Horizons ( IF 9.7 ) Pub Date : 2019-11-11 , DOI: 10.1039/c9nh00286c
Marianne Marchioni 1 , Giulia Veronesi , Isabelle Worms , Wai Li Ling , Thomas Gallon , Didier Leonard , Christelle Gateau , Mireille Chevallet , Pierre-Henri Jouneau , Laura Carlini , Chiara Battocchio , Pascale Delangle , Isabelle Michaud-Soret , Aurélien Deniaud
Affiliation  

Silver nanoparticles (AgNPs) are efficient biocides increasingly used in consumer products and medical devices. Their activity is due to their capacity to release bioavailable Ag(I) ions making them long-lasting biocides but AgNPs themselves are usually easily released from the product. Besides, AgNPs are highly sensitive to various chemical environments that triggers their transformation, decreasing their activity. Altogether, widespread use of AgNPs leads to bacterial resistance and safety concerns for humans and the environment. There is thus a crucial need for improvement. Herein, a proof of concept for a novel biocide based on AgNP assemblies bridged together by a tri-thiol bioinspired ligand is presented. The final nanomaterial is stable and less sensitive to chemical environments with AgNPs completely covered by organic molecules tightly bound via their thiol functions. Therefore, these AgNP assemblies can be considered as safer-by-design and innovative biocides, since they deliver a sufficient amount of Ag(I) for biocidal activity with no release of AgNPs, which are insensitive to transformations in the nanomaterial.

中文翻译:

由三硫醇桥联的银纳米颗粒组件制成的设计更安全的杀菌剂。

银纳米颗粒(AgNPs)是有效的杀生物剂,越来越多地用于消费产品和医疗设备中。它们的活性归因于其释放生物可利用的Ag(I)离子使它们具有持久的杀菌作用,但AgNPs本身通常很容易从产品中释放出来。此外,AgNP对触发其转化并降低其活性的各种化学环境高度敏感。总而言之,AgNPs的广泛使用导致细菌耐药性以及对人类和环境的安全性问题。因此,迫切需要改进。在本文中,提出了基于由三硫醇生物启发的配体桥接在一起的AgNP组装物的新型杀生物剂的概念证明。最终的纳米材料是稳定的,并且对化学环境不敏感,AgNP被完全覆盖的有机分子完全覆盖,通过它们的硫醇功能。因此,这些AgNP组件可被认为是设计安全且具有创新性的杀生物剂,因为它们可提供足够的Ag(I)用于杀生物活性,而不会释放对纳米材料中的转化不敏感的AgNP。
更新日期:2019-11-11
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