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Safety of slow-pulsed transcranial electrical stimulation in acute spike suppression.
Annals of Clinical and Translational Neurology ( IF 5.3 ) Pub Date : 2019-11-11 , DOI: 10.1002/acn3.50934
Mark D Holmes 1 , Rui Feng 2 , Mackenzie V Wise 1 , Chengxin Ma 2 , Ceon Ramon 1, 3 , Jinsong Wu 2 , Phan Luu 4 , Jidong Hou 5 , Li Pan 2 , Don M Tucker 4
Affiliation  

We examined the effects of slow‐pulsed transcranial electrical stimulation (TES) in suppressing epileptiform discharges in seven adults with refractory epilepsy. An MRI‐based realistic head model was constructed for each subject and co‐registered with 256‐channel dense EEG (dEEG). Interictal spikes were localized, and TES targeted the cortical source of each subject's principal spike population. Targeted spikes were suppressed in five subject's (29/35 treatment days overall), and nontargeted spikes were suppressed in four subjects. Epileptiform activity did not worsen. This study suggests that this protocol, designed to induce long‐term depression (LTD), is safe and effective in acute suppression of interictal epileptiform discharges.

中文翻译:

慢脉冲经颅电刺激在急性峰值抑制中的安全性。

我们研究了慢脉冲经颅电刺激(TES)在抑制7例难治性癫痫成人中癫痫样放电中的作用。为每个受试者构建了一个基于MRI的现实头部模型,并与256通道密集脑电图(dEEG)共同注册。局部尖峰被定位,并且TES针对每个受试者的主要尖峰种群的皮层来源。在五名受试者(总共29/35治疗日)内抑制了目标峰值,在四名受试者中抑制了非目标峰值。癫痫样活动没有恶化。这项研究表明,该方案旨在诱发长期抑郁症(LTD),在急性抑制发作期癫痫样放电方面是安全有效的。
更新日期:2019-11-11
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