Tricuspid regurgitation (TR) has long been a forgotten valve disease of benign reputation. However, TR deserves higher attention and represents a growing public health crisis. Indeed, recent epidemiological data suggest that 1.6 million US residents are affected by moderate or severe TR. Furthermore, large recent cohorts demonstrate that higher degrees of TR are associated with considerable excess mortality, independent of all background clinical and hemodynamic contexts. Finally, analysis of recent cohorts also shows that >90% of patients with moderate or severe TR are never offered surgical treatment and remain untreated. Therefore, TR is frequent, severely impacts outcomes, and is rarely treated, justifying the development of new strategies and methods for its treatment.

中文翻译：

---

三尖瓣关闭不全是一种公共卫生危机。

三尖瓣关闭不全（TR）长期以来一直是良性声誉的被遗忘的瓣膜疾病。但是，TR应该引起更多关注，并代表着日益严重的公共卫生危机。实际上，最近的流行病学数据表明，有160万美国居民受到中度或重度TR的影响。此外，最近的大量队列研究表明，较高水平的TR与相当多的过高死亡率相关，而与所有背景临床和血液动力学情况无关。最后，对近期队列的分析还显示，超过90％的中度或重度TR患者从未接受过外科手术治疗，并且仍未接受治疗。因此，TR频繁发生，严重影响疗效，并且很少得到治疗，这证明了开发新的治疗策略和方法的合理性。