Supercritical carbon dioxide adsorption was applied to incorporate three non-steroidal anti-inflammatory drugs (NSAIDs), namely nimesulide (NIM), ketoprofen (KET) and diclofenac sodium (DIC), into maize starch aerogel (MSA) and calcium alginate aerogel (CAA). The obtained composites can be used to develop tablets with a fast or controlled release of the active principle, depending on the chosen aerogel. Adsorption kinetics and isotherms were determined at 18 MPa and 40 and 60 °C to study the effect of temperature. Adsorption kinetics demonstrated for all compounds that drug loadings were higher using CAA as a support than MSA. Indeed, the maximum loadings were obtained at 60 °C and were equal to 0.13, 1.64 and 3.43 mmol_drug/g_CAA for NIM, KET and DIC, respectively. The produced composite systems were characterized by various techniques, such as scanning electron microscopy, differential scanning calorimetry, X-ray microanalysis, FT-IR and UV–vis spectroscopy. Dissolution tests revealed that the adsorption into MSA allowed a faster release of the NSAIDs than pure crystalline drugs, whereas CAA promoted a controlled release of the NSAIDs. For example, the dissolution rate of NIM, if compared with the one of the unprocessed drug, is 1.5 times faster when adsorbed into MSA and 4.6 times slower if adsorbed into CAA. Moreover, Peppas mathematical model was applied to identify the dominant factor in the drug release behavior.

应用超临界二氧化碳吸附法将三种非甾体抗炎药（NSAID），即尼美舒利（NIM），酮洛芬（KET）和双氯芬酸钠（DIC）掺入玉米淀粉气凝胶（MSA）和海藻酸钙气凝胶（CAA）中）。取决于所选择的气凝胶，所获得的复合物可用于开发具有活性成分快速释放或受控释放的片剂。在18 MPa和40和60°C下测定吸附动力学和等温线，以研究温度的影响。对所有化合物的吸附动力学表明，使用CAA作为载体的药物载量要高于MSA。实际上，最大负载量是在60°C时获得的，等于0.13、1.64和3.43 mmol_药物/ g _CAA分别用于NIM，KET和DIC。所生产的复合材料系统通过多种技术进行了表征，例如扫描电子显微镜，差示扫描量热法，X射线显微分析，傅立叶变换红外（FT-IR）和紫外可见光谱。溶出度测试表明，与纯结晶药物相比，吸收到MSA中的NSAIDs释放速度更快，而CAA则促进了NSAIDs的受控释放。例如，如果与未处理的药物之一相比，NIM的溶出度在被MSA吸收时快1.5倍，而在CAA中则慢4.6倍。此外，应用Peppas数学模型确定药物释放行为中的主导因素。