Buckwheat (Fagopyrum spp.) under the family Polygonaceae is an ancient pseudocereal with stupendous but less studied nutraceutical properties. The gluten free nature of protein, balanced amino acid profile and health promoting bioactive flavonoids make it a golden crop of future. Besides a scanty basic research, not much attention has been paid to the improvement of plant type and breeding of nutraceutical traits. Scanning of scientific literature indicates that adequate genetic variation exists for agronomic and nutritional traits in mainstream and wild gene pool of buckwheat. However, the currently employed conventional approaches together with poorly understood genetic mechanisms restrict effective utilization of the existing genetic variation in nutraceutical breeding of buckwheat. The latest trends in buckwheat genomics, particularly avalilabity of draft genome sequences for both the cultivated species (F. esculentum and F.tataricum) hold immense potential to overcome these limitations. Utilizing the transgenic hairy rot cultures, role of various transcription factors and gene families have been deduced in production and biosynthesis of bioactive flavonoids. Further, the acquisition of high-density genomics data coupled with the next-generation phenotyping will certainly improve our understanding of underlying genetic regulation of nutraceutical traits. The present paper highlights the application of multilayered omics interventions for tailoring a nutrient rich buckwheat cultivar and nutraceutical product development.

荞麦（荞麦gon科（Polygonaceae）之下的一种古老的伪谷物，具有惊人的营养品特性，但研究较少。蛋白质的无麸质性质，平衡的氨基酸组成和促进健康的生物活性类黄酮使其成为未来的黄金作物。除了基础研究很少之外，对改善植物类型和营养学特性育种的关注还很少。扫描科学文献表明，荞麦主流和野生基因库中的农艺和营养性状存在适当的遗传变异。但是，当前采用的常规方法以及对遗传机制的了解不足，限制了荞麦保健品育种中现有遗传变异的有效利用。荞麦基因组学的最新趋势，F. esculentum和F.tataricum具有克服这些局限的巨大潜力。利用转基因毛状腐烂培养物，已推断出各种转录因子和基因家族在生物活性类黄酮的生产和生物合成中的作用。此外，高密度基因组学数据的采集与下一代表型的结合无疑将增进我们对营养品性状的潜在遗传调控的理解。本文着重介绍了多层组学干预措施在定制营养丰富的荞麦品种和保健品开发中的应用。