When one person wants to communicate securely with another, he/she should contact the other person directly. This rule applies not only to human society, but also to the intracellular micro-society. In the past two decades, it has become increasingly clear that the sub-organelle regions called membrane contact sites (MCSs) are pivotal for inter-organelle transport of lipids in cells, as highlighted in the thematic review series "Interorganelle trafficking of lipids" held in Traffic in 2014-2015. In this commentary, we will describe how the currently prevailing model for lipid trafficking at MCSs was generated, and comment on three important issues that have not been explored: (a1) the principles guiding the generation of an asymmetrical inter-organelle flow of lipids in cells, (b2) the advantages in lipid trafficking at organelle contacts, and (c3) the dynamic network of inter-organelle lipid trafficking.

中文翻译：

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细胞器接触：亚细胞器区有助于促进脂质的快速和准确的细胞间运输。

当一个人想要与另一个人进行安全通信时，他/她应直接与另一个人联系。该规则不仅适用于人类社会，而且适用于细胞内的微社会。在过去的二十年中，越来越明显的是，被称为膜接触位点（MCS）的亚细胞器区域对于细胞内脂质在细胞内的细胞间运输至关重要，如专题综述系列“脂质的细胞间运输”中所强调的那样。 2014-2015年的流量。在这篇评论中，我们将描述如何生成当前流行的MCS脂质运输模型，并对尚未探讨的三个重要问题进行评论：（a1）指导非对称细胞间脂质非对称流动的原理。细胞，