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Rationale and Design of the Hamburg City Health Study
European Journal of Epidemiology ( IF 6.529 ) Pub Date : 2019-11-08 , DOI: 10.1007/s10654-019-00577-4
Annika Jagodzinski, Christoffer Johansen, Uwe Koch-Gromus, Ghazal Aarabi, Gerhard Adam, Sven Anders, Matthias Augustin, Ramona B. der Kellen, Thomas Beikler, Christian-Alexander Behrendt, Christian S. Betz, Carsten Bokemeyer, Katrin Borof, Peer Briken, Chia-Jung Busch, Christian Büchel, Stefanie Brassen, Eike S. Debus, Larissa Eggers, Jens Fiehler, Jürgen Gallinat, Simone Gellißen, Christian Gerloff, Evaldas Girdauskas, Martin Gosau, Markus Graefen, Martin Härter, Volker Harth, Christoph Heidemann, Guido Heydecke, Tobias B. Huber, Yassin Hussein, Marvin O. Kampf, Olaf von dem Knesebeck, Alexander Konnopka, Hans-Helmut König, Robert Kromer, Christian Kubisch, Simone Kühn, Sonja Loges, Bernd Löwe, Gunnar Lund, Christian Meyer, Lina Nagel, Albert Nienhaus, Klaus Pantel, Elina Petersen, Klaus Püschel, Hermann Reichenspurner, Guido Sauter, Martin Scherer, Katharina Scherschel, Ulrich Schiffner, Renate B. Schnabel, Holger Schulz, Ralf Smeets, Vladislavs Sokalskis, Martin S. Spitzer, Claudia Terschüren, Imke Thederan, Tom Thoma, Götz Thomalla, Benjamin Waschki, Karl Wegscheider, Jan-Per Wenzel, Susanne Wiese, Birgit-Christiane Zyriax, Tanja Zeller, Stefan Blankenberg

The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several important risk and prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 and 74 years of age from the general population of Hamburg, Germany, are taking part in an extensive baseline assessment at one dedicated study center. Participants undergo 13 validated and 5 novel examinations primarily targeting major organ system function and structures including extensive imaging examinations. The protocol includes validate self-reports via questionnaires regarding lifestyle and environmental conditions, dietary habits, physical condition and activity, sexual dysfunction, professional life, psychosocial context and burden, quality of life, digital media use, occupational, medical and family history as well as healthcare utilization. The assessment is completed by genomic and proteomic characterization. Beyond the identification of classical risk factors for major chronic diseases and survivorship, the core intention is to gather valid prevalence and incidence, and to develop complex models predicting health outcomes based on a multitude of examination data, imaging, biomarker, psychosocial and behavioral assessments. Participants at risk for coronary artery disease, atrial fibrillation, heart failure, stroke and dementia are invited for a visit to conduct an additional MRI examination of either heart or brain. Endpoint assessment of the overall sample will be completed through repeated follow-up examinations and surveys as well as related individual routine data from involved health and pension insurances. The study is targeting the complex relationship between biologic and psychosocial risk and resilience factors, chronic disease, health care use, survivorship and health as well as favorable and bad prognosis within a unique, large-scale long-term assessment with the perspective of further examinations after 6 years in a representative European metropolitan population.
更新日期:2019-11-11

 

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