The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several important risk and prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 and 74 years of age from the general population of Hamburg, Germany, are taking part in an extensive baseline assessment at one dedicated study center. Participants undergo 13 validated and 5 novel examinations primarily targeting major organ system function and structures including extensive imaging examinations. The protocol includes validate self-reports via questionnaires regarding lifestyle and environmental conditions, dietary habits, physical condition and activity, sexual dysfunction, professional life, psychosocial context and burden, quality of life, digital media use, occupational, medical and family history as well as healthcare utilization. The assessment is completed by genomic and proteomic characterization. Beyond the identification of classical risk factors for major chronic diseases and survivorship, the core intention is to gather valid prevalence and incidence, and to develop complex models predicting health outcomes based on a multitude of examination data, imaging, biomarker, psychosocial and behavioral assessments. Participants at risk for coronary artery disease, atrial fibrillation, heart failure, stroke and dementia are invited for a visit to conduct an additional MRI examination of either heart or brain. Endpoint assessment of the overall sample will be completed through repeated follow-up examinations and surveys as well as related individual routine data from involved health and pension insurances. The study is targeting the complex relationship between biologic and psychosocial risk and resilience factors, chronic disease, health care use, survivorship and health as well as favorable and bad prognosis within a unique, large-scale long-term assessment with the perspective of further examinations after 6 years in a representative European metropolitan population.

中文翻译：

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汉堡市健康研究的原理和设计

汉堡市健康研究（HCHS）是一项大型，前瞻性，长期，以人群为基础的队列研究，并且是一个独特的研究平台和网络，可获取有关重大慢性病中几种重要风险和预后因素的大量知识。来自德国汉堡总人口的45,000名年龄在45至74岁之间的参与者的随机样本正在一个专门的研究中心参加广泛的基线评估。参加者进行了13项有效的检查和5项新颖的检查，主要针对主要器官系统的功能和结构，包括广泛的影像学检查。该协议包括通过问卷调查验证自我报告，这些问卷涉及生活方式和环境状况，饮食习惯，身体状况和活动，性功能障碍，职业生涯，社会心理背景和负担，生活质量，数字媒体使用，职业，医学和家族病史以及医疗保健利用率。通过基因组和蛋白质组学表征完成评估。除了确定主要的慢性疾病和幸存者的经典危险因素外，其主要目的是收集有效的患病率和发病率，并基于大量检查数据，影像学，生物标志物，社会心理和行为评估，开发预测健康结果的复杂模型。邀请有冠心病，房颤，心力衰竭，中风和痴呆症风险的参与者进行访问，以对心脏或大脑进行额外的MRI检查。将通过重复的后续检查和调查以及涉及的健康和养老保险的相关个人常规数据，完成对总体样本的终点评估。该研究针对独特的大规模长期评估，针对生物学和社会心理风险与适应力因素，慢性病，卫生保健使用，幸存者和健康以及预后好坏之间的复杂关系，并进行了进一步检查。在具有代表性的欧洲大都市人口中居住了6年。