Epilepsy is characterized by unpredictable recurrent seizures resulting from hypersynchronous discharges from neuron assemblies. Increasing evidence indicates that aberrant astrocyte signaling to neurons plays an important role in driving the network hyperexcitability. Purinergic signaling is central in neuron–glia and glia–glia interactions and dysfunctions in communication pathways involving purinergic receptors have been reported in various CNS pathologies, such as Alzheimer disease, stroke, major depression, schizophrenia, and epilepsy. In the present review we will first discuss the mechanisms by which astrocytes influence neuronal activity. We will then review in more details recent evidence indicating that dysregulation of astrocyte purinergic signaling actively contributes to the appearance of abnormal neuronal activity in epilepsy.

中文翻译：

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星形胶质细胞嘌呤能信号在癫痫中的作用。

癫痫的特征是由神经元集合的超同步放电引起的不可预测的复发性癫痫发作。越来越多的证据表明，向神经元发出异常星形胶质细胞信号在驱动网络过度兴奋中起着重要作用。嘌呤能信号是神经元-神经胶质和神经胶质-神经胶质相互作用的核心，并且在涉及嘌呤能受体的通信通路中的功能障碍已在各种中枢神经系统疾病中得到报道，例如阿尔茨海默病、中风、重度抑郁症、精神分裂症和癫痫。在本综述中，我们将首先讨论星形胶质细胞影响神经元活动的机制。然后我们将更详细地回顾最近的证据，这些证据表明星形胶质细胞嘌呤能信号的失调积极促成癫痫中异常神经元活动的出现。