Fluorinated molecules have been used extensively in pharmaceutical, chemical and polymer industries. Indeed, the presence of fluorine provides unique but important physicochemical properties to the fluorinated molecules. In this review, we have discussed the effects of fluorine on the hydrogen bond network, photophysical and solvation behavior of the fluorinated molecules which have been obtained by the state of art spectroscopic and molecular dynamics simulation techniques. The substitution of fluorine in alcohols reorganizes the hydrogen bond network in its aqueous mixture by changing the orientation of water from its hydrophilic to the hydrophobic terminal. The fluorous (F···F) interaction has been found to affect photophysical and solvation properties of the fluorinated molecules significantly. The solvation time scale of the fluorinated molecules gets slower due to the fluorous interaction between probe and solvent molecules. The understanding of the role of fluorine on the hydrogen bond network, photophysical and solvation properties can be useful for the stepwise justification of the unique physicochemical properties of fluorinated molecules.

氟化分子已广泛用于制药，化学和聚合物行业。实际上，氟的存在为氟化分子提供了独特但重要的物理化学性质。在这篇综述中，我们讨论了氟对氢键网络，氟化分子的光物理和溶剂化行为的影响，这些作用是通过现有的光谱学和分子动力学模拟技术获得的。通过将水的方向从亲水端改变为疏水端，将醇中的氟取代可重新形成其水性混合物中的氢键网络。已发现氟（F···F）相互作用显着影响氟化分子的光物理和溶剂化性能。由于探针和溶剂分子之间的氟相互作用，氟化分子的溶剂化时间尺度变慢。对氟在氢键网络，光物理和溶剂化性质上的作用的了解，对于逐步证明氟化分子独特的物理化学性质可能是有用的。