The molecular and cellular mechanisms of allergen tolerance in humans have been intensively studied in the past few decades. The demonstration of epitope-specific T cell tolerance, particularly mediated by the immune suppressor functions of IL-10 led to a major conceptual change in this area more than 20 years ago. Currently, the known essential components of allergen tolerance include the induction of allergen-specific regulatory of T and B cells, the immune suppressive function of secreted factors, such as IL-10, IL-35, IL-1 receptor antagonist and TGF-β, immune suppressive functions of surface molecules such as CTLA-4 and PD-1, the production IgG4 isotype allergen-specific blocking antibodies, and decreased allergic inflammatory responses by mast cells, basophils, and eosinophils in inflamed tissues. In this review, we explain the importance of the role of IL-10 in allergen tolerance.

在过去的几十年中，已经对人类过敏原的分子和细胞机制进行了深入研究。表位特异性T细胞耐受性的证明，尤其是由IL-10的免疫抑制功能介导，导致该领域在20多年前发生了重大的概念变化。当前，已知的过敏原耐受性必需成分包括诱导T和B细胞的过敏原特异性调节，分泌因子如IL-10，IL-35，IL-1受体拮抗剂和TGF-β的免疫抑制功能。 ，CTLA-4和PD-1等表面分子的免疫抑制功能，IgG4同种型过敏原特异性阻断抗体的产生以及发炎组织中肥大细胞，嗜碱性粒细胞和嗜酸性粒细胞的变应性炎症反应减少。在这篇评论中，