The activation of toll-like receptors (TLRs) plays important roles in the immune response. The ability to control the activities of TLRs could be usable as a switch for immune response. Here we have rationally designed and synthesized a photoswitchable Pam3 CSK4 derivative-P10-to control the activation of TLR1/2. The ground-state trans-P10 was able to stimulate and activate antigen-presenting cells (APCs) by promoting TLR1/2 heterodimerization. However, cis-P10, derived from UV irradiation of trans-P10, reduced the activities of APCs by impeding the TLR1/2 heterodimerization. In the absence of UV radiation, the cis-P10 slowly returned to its ground trans state, restoring the activities of the APCs stimulation. Our results indicated that optical control of TLR1/2 heterodimerization mediated by the photoswitchable P10 offers the potential to regulate immune activation and inflammation.

中文翻译：

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通过TLR1 / 2异二聚体的光学控制来调节免疫激活。

Toll样受体（TLR）的激活在免疫反应中起重要作用。控制TLRs活性的能力可以用作免疫应答的开关。在这里，我们已经合理地设计和合成了一种可光开关的Pam3 CSK4衍生物-P10，以控制TLR1 / 2的激活。基态反式P10能够通过促进TLR1 / 2异源二聚化来刺激和激活抗原呈递细胞（APC）。但是，源自反式P10的紫外线照射的顺式P10通过阻止TLR1 / 2异二聚作用而降低了APC的活性。在没有紫外线辐射的情况下，顺式P10缓慢返回其基态，恢复了APC刺激的活性。