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Dysregulation of temporal dynamics of synchronous neural activity in adolescents on autism spectrum.
Autism Research ( IF 4.7 ) Pub Date : 2019-11-08 , DOI: 10.1002/aur.2219
Evie A Malaia 1 , Sungwoo Ahn 2 , Leonid L Rubchinsky 3, 4
Affiliation  

Autism spectrum disorder is increasingly understood to be based on atypical signal transfer among multiple interconnected networks in the brain. Relative temporal patterns of neural activity have been shown to underlie both the altered neurophysiology and the altered behaviors in a variety of neurogenic disorders. We assessed brain network dynamics variability in autism spectrum disorders (ASD) using measures of synchronization (phase‐locking) strength, and timing of synchronization and desynchronization of neural activity (desynchronization ratio) across frequency bands of resting‐state electroencephalography (EEG). Our analysis indicated that frontoparietal synchronization is higher in ASD but with more short periods of desynchronization. It also indicates that the relationship between the properties of neural synchronization and behavior is different in ASD and typically developing populations. Recent theoretical studies suggest that neural networks with a high desynchronization ratio have increased sensitivity to inputs. Our results point to the potential significance of this phenomenon to the autistic brain. This sensitivity may disrupt the production of an appropriate neural and behavioral responses to external stimuli. Cognitive processes dependent on the integration of activity from multiple networks maybe, as a result, particularly vulnerable to disruption. Autism Res 2020, 13: 24–31. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.

中文翻译:

自闭症谱系的青少年同步神经活动的时间动态失调。

自闭症谱系障碍被越来越多地理解为基于大脑中多个相互连接的网络之间的非典型信号传递。在各种神经源性疾病中,神经活动的相对时间模式已被证明是神经生理学改变和行为改变的基础。我们使用同步(锁相)强度以及静止状态脑电图(EEG)范围内神经活动的同步和失步时间(失步率)来评估自闭症谱系障碍(ASD)的脑网络动力学变异性。我们的分析表明,ASD的额前同步性更高,但失步时间更短。这也表明,神经同步的属性和行为之间的关系在ASD和典型的发育人群中是不同的。最近的理论研究表明,具有高失步比的神经网络对输入的敏感度提高了。我们的结果指出了这种现象对自闭症大脑的潜在意义。这种敏感性可能会破坏对外部刺激的适当神经和行为反应的产生。结果,依赖于来自多个网络的活动整合的认知过程可能特别容易受到破坏。我们的结果指出了这种现象对自闭症大脑的潜在意义。这种敏感性可能会破坏对外部刺激的适当神经和行为反应的产生。结果,依赖于来自多个网络的活动整合的认知过程可能特别容易受到破坏。我们的结果指出了这种现象对自闭症大脑的潜在意义。这种敏感性可能会破坏对外部刺激的适当神经和行为反应的产生。结果,依赖于来自多个网络的活动整合的认知过程可能特别容易受到破坏。Autism Res 2020,13:24–31。©2019国际自闭症研究会,Wiley Periodicals,Inc.
更新日期:2019-11-08
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