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Evolution of Epistatic Networks and the Genetic Basis of Innate Behaviors.
Trends in Genetics ( IF 11.4 ) Pub Date : 2019-11-07 , DOI: 10.1016/j.tig.2019.10.005
Robert R H Anholt 1
Affiliation  

Instinctive behaviors are genetically programmed behaviors that occur independent of experience. How genetic programs that give rise to the manifestation of such behaviors evolve remains an unresolved question. I propose that evolution of species-specific innate behaviors is accomplished through progressive modifications of pre-existing genetic networks composed of allelic variants. I hypothesize that changes in frequencies of one or more constituent allelic variants within the network leads to changes in gene network connectivity and the emergence of a reorganized network that can support the emergence of a novel behavioral phenotype and becomes stabilized when key allelic variants are driven to fixation.

中文翻译:

上位网络的演变和先天行为的遗传基础。

本能行为是独立于经验而发生的基因编程行为。遗传程序如何引起这种行为的发展仍是一个尚未解决的问题。我提出,通过对由等位基因变体组成的现有遗传网络进行逐步修改,可以实现物种特有的先天行为的进化。我假设网络中一个或多个组成等位基因变体的频率变化会导致基因网络连接性的变化以及重组网络的出现,该网络可以支持新的行为表型的出现,并且在关键等位基因变体被驱动时变得稳定固定。
更新日期:2019-11-07
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