One pot synthesis of pyrrolo[3,2,1-de]phenanthridines from 7-phenylindoles via tandem C–H olefination/aza-Michael addition,Organic Chemistry Frontiers

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One pot synthesis of pyrrolo[3,2,1-de]phenanthridines from 7-phenylindoles via tandem C–H olefination/aza-Michael addition
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2019-11-07 , DOI: 10.1039/c9qo01135h
Yumeng Yuan _{1,

2,

3,

4,

5} , Guoshuai Pan _{1,

2,

3,

4,

5} , Xiaofeng Zhang _{1,

2,

3,

4,

5} , Qiufeng Huang _{1,

2,

3,

4,

5}

Affiliation

An unprecedented one-pot C–H olefination/aza-Michael addition tandem process has been developed for the synthesis of pyrrolo[3,2,1-de]phenanthridines from 7-phenylindoles and alkenes using a [Cp*RhCl₂]₂/AgOAc/Me₄NOAc catalytic system. A relatively wide range of functional groups are tolerated, and a variety of pyrrolo[3,2,1-de]phenanthridines are obtained in good to excellent yields.

中文翻译：

一锅合成通过串联C–H烯烃/氮杂-迈克尔加成反应由7-苯基吲哚合成吡咯并[3,2,1-de]菲啶

开发了一种空前的一锅CH烯烃/氮杂-迈克尔加成串联工艺，用于使用[Cp * RhCl ₂ ] ₂ /从7-苯基吲哚和烯烃合成吡咯并[3,2,1- de ]菲啶AgOAc / Me ₄ NOAc催化系统。容许相对广泛的官能团，并且以良好至优异的产率获得了各种吡咯并[3,2,1- de ]菲啶。

更新日期：2019-11-07

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