Avipoxviruses are significant pathogens infecting a wide range of wild and domestic bird species globally. Here, we describe a novel genome sequence of magpiepox virus (MPPV) isolated from an Australian magpie. In the present study, histopathologically confirmed cutaneous pox lesions were used for transmission electron microscopic analysis, which demonstrated brick-shaped virions with regular spaced thread-like ridges, indicative of likely infectious particles. Subsequent analysis of the recovered MPPV genome positioned phylogenetically to a distinct sub-clade with the recently isolated avipoxvirus genome sequences from shearwater and canary bird species, and demonstrates a high degree of sequence similarity with CNPV (96.14%) and SWPV-2 (95.87%). The novel MPPV complete genome is missing 19 genes with a further 41 genes being truncated/fragmented compared to SWPV-2 and contains nine predicted unique genes. This is the first avipoxvirus complete genome sequence that infects Australian magpie.

中文翻译：

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来自澳大利亚喜（（Gymnorhina tibicen）的新型致病性禽痘病毒的分子特征。

鸭痘病毒是重要的病原体，可在全球范围内感染各种野生和家禽。在这里，我们描述了从澳大利亚喜isolated中分离出来的喜pi痘病毒（MPPV）的新型基因组序列。在本研究中，经组织病理学证实的皮肤痘病灶已用于透射电镜分析，显示出具有规则间隔的线状脊的砖状病毒体，表明可能存在感染性颗粒。随后对回收的MPPV基因组进行了系统分析，系统分析了用最近分离到的来自剪力水和金丝雀鸟类的禽痘病毒基因组序列，将其系统发育地定位在不同的亚进化枝上，并证明了与CNPV（96.14％）和SWPV-2（95.87％）的高度相似性）。与SWPV-2相比，新的MPPV完整基因组缺少19个基因，另外41个基因被截短/片段化，并且包含9个预测的独特基因。这是感染澳大利亚喜的第一个禽痘病毒完整基因组序列。