OBJECTIVE The relationship between acute pancreatitis and incident diabetes is unclear. We assessed whether a resolved single event of acute pancreatitis in childhood was associated with incident diabetes in adulthood. RESEARCH DESIGN AND METHODS A nationwide, population-based study of 1,802,110 Israeli adolescents (mean age 17.4 years [range 16-20]) who were examined before compulsory military service between 1979 and 2008 and whose data were linked to the Israeli National Diabetes Registry (INDR). Resolved pancreatitis was defined as a history of a single event of acute pancreatitis with normal pancreatic function at enrollment. Logistic regression analysis was applied. RESULTS Incident diabetes developed in 4.6% of subjects with resolved pancreatitis (13 of 281; none of these cases were identified as type 1 diabetes) and 2.5% among the unexposed group (44,463 of 1,801,716). Resolved acute pancreatitis was associated with incident diabetes with an odds ratio (OR) of 2.23 (95% CI 1.25-3.98) with adjustment for age, sex, and birth year. Findings persisted after further adjustments for baseline BMI and sociodemographic confounders (OR 2.10 [95% CI 1.15-3.84]). Childhood pancreatitis was associated with a diagnosis of diabetes at a younger age, with 92% of diabetes case subjects diagnosed before 40 years of age compared with 47% in the unexposed group (P = 0.002). The association accentuated when the study sample was limited to individuals of unimpaired health or normal BMI at baseline. CONCLUSIONS A history of acute pancreatitis in childhood with normal pancreatic function in late adolescence is a risk factor for incident type 2 diabetes, especially at young adulthood.

中文翻译：

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儿童胰腺炎和成年后患糖尿病的风险。

目的急性胰腺炎与糖尿病的关系尚不清楚。我们评估了儿童期急性胰腺炎已解决的单个事件是否与成年期糖尿病相关。研究设计与方法一项全国性的，以人群为基础的研究，对1979年至2008年接受义务兵役之前接受检查的1,802,110名以色列青少年（平均年龄17.4岁[范围16-20]）进行了研究，其数据与以色列国家糖尿病登记处（ INDR）。已解决的胰腺炎定义为入选时具有正常胰腺功能的急性胰腺炎的单一事件史。应用逻辑回归分析。结果4.6％的已解决的胰腺炎患者发生了突发性糖尿病（281例中有13例；这些病例中没有一例被确定为1型糖尿病）和2例。未暴露人群中占5％（1,801,716中的44,463）。已解决的急性胰腺炎与偶发性糖尿病相关，比值比（OR）为2.23（95％CI 1.25-3.98），并调整了年龄，性别和出生年份。在对基线BMI和社会人口统计学混杂因素作进一步调整后，结果仍然存在（OR 2.10 [95％CI 1.15-3.84]）。儿童胰腺炎与年轻时的糖尿病诊断有关，其中92％的糖尿病病例在40岁之前被诊断出，而未暴露组则为47％（P = 0.002）。当研究样本仅限于健康状况未受到损害或基线时BMI正常的个体时，这种关联性加剧。结论青春期晚期胰腺功能正常的儿童急性胰腺炎病史是发生2型糖尿病的危险因素，尤其是在成年期。