This study was designed to explore the potential therapeutic effects of Mg-based metal organic frameworks (MOFs) in osteoarthritis (OA) and to broaden the application field of MOFs. Mg/HCOOH-MOF was introduced and characterized by using SEM, XRD, TGA, and FTIR. ICP-MS results proved that Mg/HCOOH-MOF is stable in various physiological media and can maintain the release of Mg2+ ions for a long time. In vitro experiments were carried out to evaluate its potential application in attenuating OA. Mg/HCOOH-MOF was successfully synthesized, and results of MTT assays showed that it is biocompatible and can promote cell proliferation. qPCR results suggested that it can significantly regulate the expression of OCN, Axin2, iNOS and IL-1β, which indicated its activity in anti-inflammation and bone protection. We believe that Mg/HCOOH-MOF could benefit OA therapy.

中文翻译：

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Mg / HCOOH金属有机骨架对缓解骨关节炎的潜在治疗作用。

本研究旨在探讨基于镁的金属有机骨架（MOF）在骨关节炎（OA）中的潜在治疗作用，并拓宽MOF的应用领域。引入了Mg / HCOOH-MOF并通过SEM，XRD，TGA和FTIR对其进行了表征。ICP-MS结果表明，Mg / HCOOH-MOF在各种生理介质中均稳定，并且可以长时间保持Mg2 +离子的释放。进行了体外实验以评估其在减毒OA中的潜在应用。Mg / HCOOH-MOF已成功合成，MTT分析的结果表明，Mg / HCOOH-MOF具有生物相容性并可以促进细胞增殖。qPCR结果表明，它可以显着调节OCN，Axin2，iNOS和IL-1β的表达，这表明它具有抗发炎和保护骨骼的作用。