Antimicrobial screening usually analyses the effects of natural or synthetic molecules against pathogens. McAuley et al. changed this paradigm, testing the effect of synthetic compounds against the sporulation of the nonpathogenic bacterium Streptomyces venezuelae. They discovered a novel DNA-targeting antibiotic effective against pathogens.

中文翻译：

---

非病原性细菌作为抗微生物高通量筛选的目标。

抗菌筛查通常分析天然或合成分子对病原体的影响。McAuley等。改变了这一范例，测试了合成化合物对非病原性细菌委内瑞拉链霉菌的孢子形成的作用。他们发现了一种新型的靶向DNA的抗生素，可有效对抗病原体。