Segmented, double-stranded RNA viruses of the Reoviridae family tightly regulate the activity of encapsidated polymerases to mediate the transition between genome replication and iterative rounds of multipartite transcription within a particle. By resolving multiple in situ structures of the transcribing complex, a new study reveals enzyme conformational changes and RNA trajectories during specific transcriptional states that support an ‘ouroboros’ model of conservative transcription for a member of the Reoviridae family.

中文翻译：

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呼肠孤病毒科转录不仅仅是一个打开和关闭的案例。

呼肠孤病毒科的分段双链 RNA 病毒严格调节包壳聚合酶的活性，以介导基因组复制和粒子内多部分转录的迭代轮次之间的过渡。通过解析转录复合物的多个原位结构，一项新研究揭示了特定转录状态下的酶构象变化和 RNA 轨迹，这些变化支持呼肠孤病毒科成员保守转录的“衔尾蛇”模型。