Recent preclinical and clinical studies have indicated that the galanin peptide family may regulate glucose metabolism and alleviate insulin resistance, which diminishes the probability of type 2 diabetes mellitus. The galanin was discovered in 1983 as a gut-derived peptide hormone. Subsequently, galanin peptide family was found to exert a series of metabolic effects, including the regulation of gut motility, body weight and glucose metabolism. The galanin peptide family in modulating glucose metabolism received recently increasing recognition because pharmacological activiation of galanin signaling might be of therapeutic value to improve insuin resistance and type 2 diabetes mellitus. To date, however, few papers have summarized the role of the galanin peptide family in modulating glucose metabolism and insulin resistance. In this review we summarize the metabolic effect of galanin peptide family and highlight its glucoregulatory action and discuss the pharmacological value of galanin pathway activiation for the treatment of glucose intolerance and type 2 diabetes mellitus.

中文翻译：

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甘丙肽家族对葡萄糖代谢的调控

最近的临床前和临床研究表明，甘丙肽家族可以调节葡萄糖代谢并减轻胰岛素抵抗，从而降低患 2 型糖尿病的概率。甘丙肽于 1983 年被发现是一种源自肠道的肽激素。随后，甘丙肽家族被发现发挥一系列代谢作用，包括调节肠道运动、体重和葡萄糖代谢。甘丙肽家族在调节葡萄糖代谢方面最近得到越来越多的认可，因为甘丙肽信号的药理学激活可能对改善胰岛素抵抗和 2 型糖尿病具有治疗价值。然而，迄今为止，很少有论文总结甘丙肽家族在调节葡萄糖代谢和胰岛素抵抗中的作用。