There is a large therapeutic gap in the treatment of sickle cell disease (SCD). Recent studies demonstrated the presence of pathophysiological and microbial changes in the intestine of patients with SCD. The intestinal microbes have also been found to regulate neutrophil ageing and possible basal activation of circulating neutrophils. Both aged and activated neutrophils are pivotal for the pathogenesis of vaso-occlusive crisis in SCD. In this paper, we will provide an overview of the intestinal pathophysiological and microbial changes in SCD. Based on these changes, we will propose therapeutic approaches that could be investigated for treating SCD.

中文翻译：

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镰状细胞病的肠道病理生理和微生物变化：治疗干预的潜在目标。

镰状细胞病（SCD）的治疗存在巨大的治疗空白。最近的研究表明，SCD患者肠道中存在病理生理和微生物变化。还发现肠道微生物可调节中性粒细胞的衰老和可能的循环中性粒细胞的基础活化。老年和活化中性粒细胞对于SCD血管闭塞性危机的发病机理都至关重要。在本文中，我们将概述SCD的肠道病理生理和微生物变化。基于这些变化，我们将提出可用于治疗SCD的治疗方法。