OBJECTIVES To compare the effect of sildenafil citrate (SC) and low molecular weight heparin (LMWH) on neonatal birth weight (BW) and the fetoplacental blood flow in pregnancies with FGR. STUDY DESIGN A parallel groups, randomized clinical trial was conducted at a university hospital, between June 2017 and September 2018, involving 100 pregnant women with placental mediated FGR between 28 and 35 weeks of gestation who were randomly assigned to receive either SC or LMWH started at FGR diagnosis till delivery. RESULTS The neonatal BW in LMWH group was higher than SC group (p < 0.000) with a longer time from randomization till delivery, LMWH group had significant improvement in Ut A PI, UA PI, and MCA PI compared with SC treated group with p values 0.005, <0.000001, and 0.014, respectively. CONCLUSION The neonatal BW, time from randomization to delivery, and fetoplacental blood flow indices were significantly better with LMWH use compared with SC.

中文翻译：

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母体低分子量肝素与枸橼酸西地那非用于胎儿生长受限：随机、平行组、开放标签临床试验。

目的 比较柠檬酸西地那非 (SC) 和低分子肝素 (LMWH) 对 FGR 妊娠中新生儿出生体重 (BW) 和胎盘血流量的影响。研究设计 2017 年 6 月至 2018 年 9 月在大学医院进行了一项平行组随机临床试验，涉及 100 名妊娠 28 至 35 周之间有胎盘介导的 FGR 的孕妇，她们被随机分配接受 SC 或 LMWH FGR 诊断直到交付。结果 LMWH 组新生儿 BW 高于 SC 组（p < 0.000），从随机化到分娩的时间更长，LMWH 组与 SC 治疗组相比，Ut A PI、UA PI 和 MCA PI 显着改善，p 值分别为 0.005、<0.000001 和 0.014。结论 新生儿 BW，