Macrophages act as scavengers, modulating the immune response against pathogens and maintaining tissue homeostasis. Metabolism governs macrophage differentiation, polarization, mobilization, and the ability to mount an effective antitumor response. However, in cancer, the tumor microenvironment (TME) can actively reprogram macrophage metabolism either by direct exchange of metabolites or through cytokines and other signaling mediators. Thus, metabolic reprogramming holds potential for modulating macrophages and developing new therapeutic approaches. In this review, we provide an overview of macrophage metabolism as it relates to macrophage function and plasticity in cancer.

巨噬细胞起清除剂的作用，调节针对病原体的免疫反应并维持组织稳态。代谢决定着巨噬细胞的分化，极化，动员以及启动有效抗肿瘤反应的能力。但是，在癌症中，肿瘤微环境（TME）可以通过直接交换代谢物或通过细胞因子和其他信号传导介质来主动重编程巨噬细胞代谢。因此，代谢重编程具有调节巨噬细胞和开发新的治疗方法的潜力。在这篇综述中，我们概述了巨噬细胞代谢，因为它与癌症中的巨噬细胞功能和可塑性有关。