Lysosomes are key cellular catabolic centers that also perform fundamental metabolic, signaling and quality control functions. Lysosomes are not static and they respond dynamically to intra- and extracellular stimuli triggering changes in organelle numbers, size and position. Such physical changes have a strong impact on lysosomal activity ultimately influencing cellular homeostasis. In this review, we summarize the current knowledge on lysosomal size regulation, on its physiological role(s) and association to several disease conditions.

中文翻译：

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溶酶体大小很重要。

溶酶体是关键的细胞分解代谢中心，它们还执行基本的代谢，信号传导和质量控制功能。溶酶体不是静态的，它们对细胞内和细胞外刺激产生动态反应，从而触发细胞器数量，大小和位置的变化。此类物理变化对溶酶体活性有重大影响，最终影响细胞体内平衡。在这篇综述中，我们总结了有关溶酶体大小调节，其生理作用以及与多种疾病状况相关性的最新知识。