The present study describes the isolation of convolvine from the roots of the Tunisian plant Convolvulus dorycnium L. and its synthesis through a four-step sequence starting from tropine. Then, an efficient synthesis of N-(het)aryltropanes derivatives by a sequence of a palladium-catalyzed N-arylationof convolvine has been established. This strategy enabled access to unknown tropane scaffolds of biological interests.

中文翻译：

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通过钯催化的布赫瓦尔德-哈特维格交叉偶联反应合成N-（杂）芳基香豆素衍生物

本研究描述了从突尼斯植物空心菜的根中分离出空心菜素，并通过从四氢吡啶开始的四步序列对其进行了合成。然后，已经建立了通过钯催化的卷心菜的N-芳基化反应的序列有效合成N-（het）aryltropanes衍生物的方法。该策略使得能够获得具有生物学意义的未知的托烷骨架。