Chemical investigation of an undescribed Australian fungus, Aspergillus nanangensis, led to the identification of the nanangenines – a family of seven new and three previously reported drimane sesquiterpenoids. The structures of the nanangenines were elucidated by detailed spectroscopic analysis supported by single crystal X-ray diffraction studies. The compounds were assayed for in vitro activity against bacteria, fungi, mammalian cells and plants. Bioinformatics analysis, including comparative analysis with other acyl drimenol-producing Aspergilli, led to the identification of a putative nanangenine biosynthetic gene cluster that corresponds to the proposed biosynthetic pathway for nanangenines.

中文翻译：

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Nanangenines：作为一种新型澳大利亚真菌Nanangensis的主要代谢产物群，drimane倍半萜类化合物

对一种未描述的澳大利亚真菌南曲霉（Aspergillus nanangensis）的化学研究导致鉴定了nanangenines，这是一个由7个新的和以前报道的3个drimane倍半萜类化合物组成的家族。通过单晶X射线衍射研究支持的详细光谱分析，阐明了鞣花碱的结构。测定化合物对细菌，真菌，哺乳动物细胞和植物的体外活性。生物信息学分析，包括与其他酰基树烯醇生产的曲霉的比较分析，导致鉴定出推定的南gen碱生物合成基因簇，该基因簇与拟议的南nan碱生物合成途径相对应。