Netrin is a prototypical axon guidance cue. Structural studies have revealed how netrin interacts with the deleted in colorectal cancer (DCC) receptor, other receptors, and co-factors for signaling. Recently, genetic studies suggested that netrin is involved in neuronal haptotaxis, which requires a reversible adhesion process. Structural data indicate that netrin can also mediate trans-adhesion between apposing cells decorated with its receptors on the condition that the auxiliary guidance cue draxin is present. Here, we propose that netrin is involved in conditional adhesion, a reversible and localized process that can contribute to cell adhesion and migration. We suggest that netrin-mediated adhesion and signaling are linked, and that local environmental factors in the ventricular zone, the floor plate, or other tissues coordinate its function.

中文翻译：

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Netrin通过DCC增强信号和附着力。

Netrin是轴突指导的原型。结构研究表明netrin如何与大肠癌（DCC）受体，其他受体和信号辅助因子中的缺失相互作用。最近，遗传学研究表明netrin参与神经元触觉控制，这需要可逆的粘附过程。结构数据表明，在存在辅助指导线索draxin的条件下，netrin还可以介导装饰有其受体的并置细胞之间的反粘连。在这里，我们建议netrin参与条件粘附，这是一个可逆的局部过程，可有助于细胞粘附和迁移。我们建议netrin介导的粘附和信号传导是联系在一起的，并且在心室区，地板或其他组织中的局部环境因素协调了其功能。