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Anti-ageing gene therapy: Not so far away?
Ageing Research Reviews ( IF 13.1 ) Pub Date : 2019-11-05 , DOI: 10.1016/j.arr.2019.100977
Alexander Vaiserman 1 , Elena De Falco 2 , Alexander Koliada 1 , Olga Maslova 3 , Carmela Rita Balistreri 4
Affiliation  

Improving healthspan is the main objective of anti-ageing research. Currently, innovative gene therapy-based approaches seem to be among the most promising for preventing and treating chronic polygenic pathologies, including age-related ones. The gene-based therapy allows to modulate the genome architecture using both direct (e.g., by gene editing) and indirect (e.g., by viral or non-viral vectors) approaches. Nevertheless, considering the extraordinary complexity of processes involved in ageing and ageing-related diseases, the effectiveness of these therapeutic options is often unsatisfactory and limited by their side-effects. Thus, clinical implementation of such applications is certainly a long-time process that will require many translation phases for addressing challenges. However, after overcoming these issues, their implementation in clinical practice may obviously provide new possibilities in anti-ageing medicine. Here, we review and discuss recent advances in this rapidly developing research field.



中文翻译:

抗衰老基因疗法:不远吗?

改善健康寿命是抗衰老研究的主要目标。当前,基于基因治疗的创新方法似乎是预防和治疗包括年龄相关疾病在内的慢性多基因病理学最有前途的方法之一。基于基因的疗法允许使用直接(例如,通过基因编辑)和间接(例如,通过病毒或非病毒载体)方法来调节基因组结构。然而,考虑到与衰老和与衰老相关的疾病所涉及的过程异常复杂,这些治疗选择的有效性通常不能令人满意,并且受其副作用的限制。因此,此类应用程序的临床实施无疑是一个漫长的过程,将需要许多翻译阶段来应对挑战。但是,克服了这些问题之后,它们在临床实践中的实施显然可以为抗衰老医学提供新的可能性。在这里,我们回顾和讨论在这个快速发展的研究领域中的最新进展。

更新日期:2019-11-05
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