Although there have been suggestions that altered cognitive control and food reward sensitivity contribute to overeating in obese individuals, neurophysiological correlates of these mechanisms have been poorly investigated. The current study investigated event-related potentials (ERP) in 24 severely obese and 26 normal weight individuals in fasting condition, using a novel Simon task with food and object distractors. The study showed that conflict in the Simon task for the food distractor increased with hunger in both groups but was larger with respect to a neutral condition only in the obese individuals. ERP showed higher N1amplitudes in both groups for food distractor, reflecting early food processing. The P2 latency was delayed and the effect of distractors on N2 amplitude was smaller in the obese subjects, reflecting altered neural mechanisms associated with selective attention and cognitive control, all contributing hypothetically to delay response selection of these individuals faced with food distractor.

中文翻译：

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ERP 与正常体重和严重肥胖的减肥手术候选人的认知控制和食物相关处理的相关性：使用新设计的 Simon 任务收集的数据

尽管有人建议改变的认知控制和食物奖励敏感性有助于肥胖个体暴饮暴食，但这些机制的神经生理学相关性研究很少。当前的研究调查了 24 名严重肥胖者和 26 名正常体重者在禁食状态下的事件相关电位 (ERP)，使用一种带有食物和物体干扰物的新型西蒙任务。研究表明，西蒙任务中食物干扰者的冲突在两组中都随着饥饿而增加，但仅在肥胖个体中就中性条件而言更大。ERP 显示两组食物干扰物的 N1 幅度较高，反映早期食物加工。肥胖受试者的 P2 潜伏期延迟，干扰物对 N2 振幅的影响较小，